Rosanna Lauren Arquette (born August 10, 1959) is an American actress, film director, and film producer.
Arquette was born in New York City, the daughter of Brenda "Mardi" Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor and director. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and Arquette's father was a convert to Islam and claimed to be a descendant of explorer Meriwether Lewis.Arquette's siblings are actors Patricia, Alexis, Richmond and David Arquette. Arquette is also the sister-in-law of Courteney Cox, who is married to Arquette's brother David.
In 1963, Arquette's family moved to Chicago, where her father managed The Second City theater for several years. When she was eleven years old, her parents moved to a commune in Front Royal, Virginia. Arquette did not do well at school. In 1974, she hitchhiked across the country with three older teenagers, eventually going to San Francisco, where she worked at renaissance and Dickens fairs. Her professional theater debut was May 27, 1977, appearing in the Story Theatre Musical production of Ovid's The Metamorphoses at the Callboard Theatre on Melrose Place in Los Angeles.
In 1989, Scorsese offered her a part in New York Stories. Since then, Arquette has appeared, with few exceptions, in one or in several movies each year, some of them of notable interest, like Pulp Fiction and the David Cronenberg film, Crash. An offbeat choice, however, was to fly downunder and make the Australian film Wendy Cracked a Walnut (1990) (also known as Almost). An expensive film, and a huge box office flop, only the musical score by Bruce Smeaton was generally noted by critics, for its musical innovation. In 1990, Arquette appeared on the cover and in a nude pictorial in Playboy's September issue, although she claimed it was without her prior knowledge or consent.
In recent years, Arquette has also been expanding into direction. Recent films which she has directed include the documentaries Searching for Debra Winger (2002) and All We Are Saying (2005); she also produced both projects.
Arquette appeared in the short running What About Brian as Nicole Varsi and on Showtime's The L Word as Cherie Jaffe.
Rosanna joins Fit Parent Magazine  as Associate Publisher / Editor at Large Los Angeles.
Her 1986 marriage to composer James Newton Howard also ended in divorce. English pop and rock star Peter Gabriel recorded the hit "In Your Eyes" inspired by a brief reconciliation with the actress. Arquette married restaurateur John Sidel in 1993. One year later their daughter, Zoe Blue Sidel, was born. Arquette went on working intensively, which meant she was often away from home. The couple divorced in 1999. Arquette became engaged to entertainment executive, David Codikow, in September 2001. Arquette promotes awareness of breast cancer, while continuing with her work as a director. Her mother died of breast cancer in 1997. In 2002 her critically acclaimed documentary Searching for Debra Winger was released. In the film, Arquette interviews prominent and respected actresses (mostly between the ages of 30 and 60) to explore the practicalities for a working actress to successfully maintain a family.
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